Nour-Eddine Rhaleb
Biography
Nour-Eddine Rhaleb is a Professor (Research) in the department of Physiology.
Nour-Eddine Rhaleb is an accomplished investigator in physiology and pharmacology, specializing in hypertension and cardiovascular diseases, particularly heart failure. With a robust background in pre-clinical rodent models and molecular mechanisms, Rhaleb's research has significantly contributed to understanding the pathophysiology of hypertension, cardiac remodeling, and dysfunction. His laboratory has received consistent support from prestigious funding agencies like the National Institutes of Health (NIH) and the American Heart Association (AHA), resulting in numerous publications in esteemed peer-reviewed journals.
Rhaleb's current collaborative project, titled "Coronary microcirculation endothelial dysfunction: A promising therapeutic target for heart failure with preserved ejection fraction pathogenesis," aims to investigate innovative therapeutic strategies to halt the progression of heart failure. Leveraging expertise in breeding transgenic mice and conducting in vivo cardiac function evaluations, his team will explore the impact of endothelial cell-specific ER stress disruption on cardiomyocyte function. By fostering collaboration between multiple institutions, Rhaleb ensures rigor, transparency, and reproducibility in his research endeavors.
Office Address
Integrative Bioscience Center,
Suite 1417 6135 Woodward Ave
Detroit, MI
Education/Training
University of Sherbrooke (Canada) Ph.D. Pharmacology,1992
University of Sherbrooke (Canada) M.Sc. Pharmacology,1987
University of Sherbrooke (Canada) B.Sc. Microbiology,1985
Postgraduate Training
Postdoctoral Research Fellow, Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Michigan. 1992-1994
Office Phone
313-432-7314
Honors and Awards
Rhaleb's contributions have been recognized with honors such as Fellowship of the American Association for the Advancement of Science (AAAS) and Fellowship of the American Heart Association.
Publications
- Srinivas B, Alluri K, O’Regan JD, Peng H, Ortiz, PA, Xu J, Sabbah HN, Belmadani S, Rhaleb NE, Matrougui, K. Female mice are not protected from heart failure with preserved ejection fraction pathogenesis. x citations Role: Participated in designing the experiment, analyzing data, and writing the manuscript. Co-corresponding author
- Srinivas BK, Bourdi A, O’Regan JD, Malavalli KD, Rhaleb NE, Belmadani S, Matrougui, K. Interleukin-1ï¢ disruption protects male mice from HFpEF pathogenesis. J Am Heart Assoc. 2023 Jul 18;12(14):e029668. Doi: 10.1161/JAHA.122.029668. Epub 2023 Jun 22. PMID: 37345828 PMCID: PMC10382083. Role: Participated in designing the experiment, analyzing data, and writing the manuscript.
- Suhail H, Peng H, Xu J, Sabbah HN, Matrougui K, Lao TD, Ortiz PA, Bernstein KE, Rhaleb NE. Knockout of ACE-N facilitates improved cardiac function after myocardial infarction. J Mol Cell Cardiol Plus. 2023 March;3:100024. PMID: 36778784 PMCID: PMC9910327 DOI: 10.1016/j.jmccpl.2022.100024. X citations Role: Designed and wrote the manuscript.
- Kassem KM, Ali M, Rhaleb NE. Interleukin-4: Its Role in Hypertension, Atherosclerosis, Valvular and Non-Valvular Cardiovascular Diseases. J Cardiovas Pharmacol Ther. 25(1):7-14, 2020. doi: 10.1177/1074248419868699. PMID: 31401864 5 citations Role: Designed and wrote the manuscript.
- Kassem KM, Vaid S, Peng H, Sarkar S, Rhaleb NE. Tβ4-Ac-SDKP pathway: Any relevance for the cardiovascular system? Can J Physiol Pharmacol. 97(7):589-599, 2019 PMID: 30854877 5 citations Role: Designed and wrote the manuscript.